💉 IV Bolus Single Dose

For IV Bolus administration of a single dose, the following parameters are calculated as described.

Parameters that do not depend on a terminal slope

Parameter name	Parameter code in output	Description of calculation
AUC all linear C0	AUC_all_lin_C0	Sum of partial AUC values for all time points including C0 using the linear method
AUC all linear C0/Dose	AUC_all_lin_C0_D	$\frac{AUC\mathrm{\_}all\mathrm{\_}lin\mathrm{\_}C0}{Dose}$
AUC all linlog C0	AUC_all_log_C0	Sum of partial AUC values for all time points including C0 using the linear up log down method
AUC all linlog C0/Dose	AUC_all_log_C0_D	$\frac{AUC\mathrm{\_}all\mathrm{\_}log\mathrm{\_}C0}{Dose}$
AUC last linear C0	AUC_last_lin_C0	Sum of partial AUC values from time of dose administration (C0) through TLAST using the linear method
AUC last linear C0/Dose	AUC_last_lin_C0_D	$\frac{AUC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0}{Dose}$
AUC last linlog C0	AUC_last_log_C0	Sum of partial AUC values from time of dose administration (C0) through TLAST using the linear up log down method
AUC last linlog C0/Dose	AUC_last_log_C0_D	$\frac{AUC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0}{Dose}$
AUMC last linear C0	AUMC_last_lin_C0	Sum of partial AUMC values from time of dose administration (C0) through TLAST using the linear methd
AUMC last linlog C0	AUMC_last_log_C0	Sum of partial AUMC values from time of dose administration (C0) through TLAST using the linear up log down methd
C0	C0	Log-linear extrapolation back to time of dose administration using the first 2 measured concentration time point.
Last measurable concentration	Clast	Analyzed concentration value greater than zero with the largest associated time value.
Dose	Dose	Dose amount
MRT last linear C0	MRT_last_lin_C0	$\frac{AUMC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0}{AUC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0}$
MRT last linlog C0	MRT_last_lin_C0	$\frac{AUMC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0}{AUC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0}$
Number of BLQ samples	N_blq	Total number of observed concentrations reported as "BLQ"
Number of missing samples	N_miss	Total number of observed concentrations reported as "Missing"
Number of samples	N_samp	Total number of records in the observed concentration column. Observations that are
Time of Clast	Tlast	Value in the time column the corresponds to Clast.
Partial AUC from C0 linear	pAUC_C0_lin	Partial area under the curve from C0 to the first measured timepoint using the linear method
Partial AUC from C0 linlog	pAUC_C0_log	Partial area under the cuver from C0 to the first measured timepoint using the linear up log down methd

Parameters that depend on a terminal slope

Parameter name	Parameter code in output	Description of calculation
Percent AUC extrapolated to C0 linear	AUC_extrap_C0_lin	$100\ast [\frac{pAUC\mathrm{\_}C0\mathrm{\_}lin}{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}]$
Percent AUC extrapolated to C0 linlog	AUC_extrap_C0_log	$100\ast [\frac{pAUC\mathrm{\_}C0\mathrm{\_}log}{AUC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0}]$
AUC infinity linear C0	AUC_inf_lin_C0	$AUC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0+\frac{Clast}{kel}$
AUC infinity linear C0/Dose	AUC_inf_lin_C0_D	$\frac{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}{Dose}$
Percent extrapolated AUC infinity linear C0	AUC_inf_lin_C0_extrap	$100\ast [\frac{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0-AUC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0}{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}]$
AUC infinity linlog C0	AUC_inf_log_C0	$AUC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0+\frac{Clast}{kel}$
AUC infinity linlog C0/Dose	AUC_inf_log_C0_D	$\frac{AUC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0}{Dose}$
Percent extrapolated AUC infinity linlog C0	AUC_inf_log_C0_extrap	$100\ast [\frac{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0-AUC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0}{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}]$
AUMC infinity linear C0	AUMC_inf_lin_C0	$AUMC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0+\frac{Clast\ast Tlast}{kel}+\frac{Clast}{ke{l}^2}$
Percent extrapolated AUMC infinity linear C0	AUMC_inf_lin_C0_extrap	$100\ast [\frac{AUMC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0-AUMC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0}{AUMC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}]$
AUMC infinity linlog	AUMC_inf_log_C0	$AUMC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0+\frac{Clast\ast Tlast}{kel}+\frac{Clast}{ke{l}^2}$
Percent extrapolated AUMC infinity linlog C0	AUMC_inf_log_C0_extrap	$100\ast [\frac{AUMC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0-AUMC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0}{AUMC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0}]$
CL linear	CL_lin_C0	$\frac{Dose}{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}$
CL linlog	CL_log_C0	$\frac{Dose}{AUC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0}$
MRT last linear	MRT_last_lin_C0	$\frac{AUMC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0}{AUC\mathrm{\_}last\mathrm{\_}lin\mathrm{\_}C0}$
MRT last linlog	MRT_last_log_C0	$\frac{AUMC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0}{AUC\mathrm{\_}last\mathrm{\_}log\mathrm{\_}C0}$
MRT linear	MRT_lin_C0	$\frac{AUMC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}{AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}$
MRT linlog	MRT_log_C0	$\frac{AUMC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0}{AUC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0}$
Vss linear	Vss_lin_C0	$MRT\mathrm{\_}lin\mathrm{\_}C0\ast CL\mathrm{\_}lin\mathrm{\_}C0$
Vss linlog	Vss_log_C0	$MRT\mathrm{\_}log\mathrm{\_}C0\ast CL\mathrm{\_}log\mathrm{\_}C0$
Vz linear	Vz_lin_C0	$\frac{Dose}{kel\ast AUC\mathrm{\_}inf\mathrm{\_}lin\mathrm{\_}C0}$
Vz linlog	Vz_log_C0	$\frac{Dose}{kel\ast AUC\mathrm{\_}inf\mathrm{\_}log\mathrm{\_}C0}$
Terminal slope group	group	Group number for each estimated terminal slope. For each profile at least one terminal slope is calculated. All parameters that are dependent on estimation of the terminal slope are also calcualted and given the same group number.
Terminal slope intercept	intercept	Intercept of linear regression.
Terminal slope	kel	Negative of estimated slope by linear regression of the natural log-transformed analyzed concentrations and the time of each observation.
Terminal slope adjusted r-squared	kel_adjr2	$1-(1-kel\mathrm{\_}r2)\ast [\frac{kel\mathrm{\_}n-1}{kel\mathrm{\_}n-2}]$
Terminal slope lower time point	kel_low	Smallest time value used to calculate the terminal slope.
Number of data points in terminal slope calculation	kel_n	Number of samples included in teh terminal slope calculation.
Terminal slope r-squared	kel_r2	r2 value from terminal slope linear regression.
Terminal slope span	kel_span	$\frac{kel\mathrm{\_}upper-kel\mathrm{\_}low}{kel\mathrm{\_}thalf}$
Terminal half life	kel_thalf	$\frac{ln(2)}{kel}$
Terminal slope upper time point	kel_upper	Largest time value used to calculate the terminal slope.