πͺ Extrapolation and Interpolation Methods β
Various extrapolation and interpolation methods are used during the calculation of some PK parameters. The mathematical expressions for these methods are shown below.
Linear interpolation β
If a concentration value must be interpolated between two observed concentration values using linear interpolation, the following equation will be used:
Logarithimic interpolation β
If a concentration value must be interpolated between two observed concentration values using logarithmic interpolation, the following equation will be used:
Logarithmic extrapolation for Ctau β
If a value of Ctau is not observed in the dataset, it can be estimated by extrapolating from the last observed concentration using the following equation:
Logarithim extrapolation for C0 β
Backward extrapolation to estimate the concentration at time 0 is performed using the first 2 measured concentrations following dose administration. The first step is to perform a linear regression and estimating the slope (
Then the value for C0 is calculated using the following equation: