Skip to content

πŸ’Š Extravascular Single Dose ​

For extravascular administration of a single dose, the following parameters are calculated as described. The extravascular route includes oral, topical, sublingual, subcutaneous, intramuscular, rectal, and any other route that is not intravenous.

Parameters that do not depend on a terminal slope ​

Parameter nameParameter code in outputDescription of calculation
AUC all linearAUC_all_linSum of partial AUC values for all time points using the linear method
AUC all linear/DoseAUC_all_lin_DAUC_all_linDose
AUC all linlogAUC_all_logSum of partial AUC values for all time points using the linear up log down method
AUC all linlog/DoseAUC_all_log_DAUC_all_logDose
AUC last linearAUC_last_linSum of partial AUC values from time of dose administration through Tlast using the linear method
AUC last linear/DoseAUC_last_lin_DAUC_last_linDose
AUC last linlogAUC_last_logSum of partial AUC values from time of dose administration through Tlast using the linear up log down method
AUC last linlog/DoseAUC_last_log_DAUC_last_logDose
AUMC all linearAUMC_all_linSum of partial AUMC values for all time points using the linear methd
AUMC all linlogAUMC_all_logSum of partial AUMC values for all time points using the linear up log down methd
AUMC last linearAUMC_last_linSum of partial AUMC values from time of dose administration through Tlast using the linear methd
AUMC last linlogAUMC_last_logSum of partial AUMC values from time of dose administration through Tlast using the linear up log down methd
Last measurable concentrationClastAnalyzed concentration value greater than zero with the largest associated time value.
Maximum concentrationCmaxMaximum concentration value in the analyzed concentration column.
Cmax/DoseCmax_DCmaxDose
Minimum concentrationCminMinimum concentration value in the analyzed concentration column.
DoseDoseDose amount
Time of DoseDose_timeTime of dose administration
Number of BLQ samplesN_blqTotal number of observed concentrations reported as "BLQ"
Number of missing samplesN_missTotal number of observed concentrations reported as "Missing"
Number of samplesN_sampTotal number of records in the observed concentration column. Observations that are below the limit of quantitation (BLQ) are counted, but missing observations are not counted.
Lag timeTlagValue in time column that corresponds to the last concentration with a value of 0 after the dose administration time but before the first analyzed concentration value greater than zero.
Time of ClastTlastValue in the time column the corresponds to Clast.
Time of CmaxTmaxValue in time column that corresponds to the maximum concentration. If there are two identical values at the maximum concentration, the earliest time is reported.
Time of CminTminValue in time column that corresponds to the minimum concentration. If there are two identical values at the minimum concentration, the earliest time is reported.

Parameters that depend on a terminal slope ​

Parameter nameParameter code in outputDescription of calculation
AUC infinity linearAUC_inf_linAUC_last_lin+Clastkel
AUC infinity linear/DoseAUC_inf_lin_DAUC_inf_linDose
Percent extrapolated AUC infinity linearAUC_inf_lin_extrap100βˆ—[AUC_inf_linβˆ’AUC_last_linAUC_inf_lin]
AUC infinity linlogAUC_inf_logAUC_last_log+Clastkel
AUC infinity linlog/DoseAUCINFLOG_DAUC_inf_logDose
Percent extrapolated AUC infinity linlogAUC_inf_log_extrap100βˆ—[AUC_inf_logβˆ’AUC_last_logAUC_inf_log]
AUMC infinity linearAUMC_inf_linAUMC_last_lin+Clastβˆ—Tlastkel+Clastkel2
Percent extrapolated AUMC infinity linearAUMC_inf_lin_extrap100βˆ—[AUMC_inf_linβˆ’AUMC_last_linAUMC_inf_lin]
AUMC infinity linlogAUMC_inf_logAUMC_last_log+Clastβˆ—Tlastkel+Clastkel2
Percent extrapolated AUMC infinity linlogAUMC_inf_log_extrap100βˆ—[AUMC_inf_logβˆ’AUMC_last_logAUMC_inf_log]
CL/F linearCL_f_linDoseAUC_inf_lin
CL/F linlogCL_f_logDoseAUC_inf_log
MRT last linearMRT_last_linAUMC_last_linAUC_last_lin
MRT last linlogMRT_last_logAUMC_last_logAUC_last_log
MRT linearMRT_linAUMC_inf_linAUC_inf_lin
MRT linlogMRT_logAUMC_inf_logAUC_inf_log
Vz/F linearVz_f_linDosekelβˆ—AUC_inf_lin
Vz/F linlogVz_f_logDosekelβˆ—AUC_inf_log
Terminal slope groupgroupGroup number for each estimated terminal slope. For each profile at least one terminal slope is calculated. All parameters that are dependent on estimation of the terminal slope are also calcualted and given the same group number.
Terminal slope interceptinterceptIntercept of linear regression.
Terminal slopekelNegative of estimated slope by linear regression of the natural log-transformed analyzed concentrations and the time of each observation.
Terminal slope adjusted r-squaredkel_adjr21βˆ’(1βˆ’kel_r2)βˆ—[kel_nβˆ’1kel_nβˆ’2]
Terminal slope lower time pointkel_lowSmallest time value used to calculate the terminal slope.
Number of data points in terminal slope calculationkel_nNumber of samples included in teh terminal slope calculation.
Terminal slope r-squaredkel_r2r2 value from terminal slope linear regression.
Terminal slope spankel_spankel_upperβˆ’kel_lowkel_thalf
Terminal half lifekel_thalfln(2)kel
Terminal slope upper time pointkel_upperLargest time value used to calculate the terminal slope.